A study published in the journal Oncotarget shows how a combination of Vitamin C and the antibiotic Doxycycline can kill cancer stem cells. This could lead to a more effective cancer treatment in the future.
Cancer stem cells are the cells that allow tumors to grow and spread. These cells can get a new fuel source, so they can resistant to chemotherapy and other cancer treatment. A combination therapy of Vitamin C and Doxycycline can prevent this resistance.
A University of Salford team published this study in Oncotarget under the leadership of Professor Michael Lisanti. Lisanti stated that his team hypothesized that cancer cells are resistant because they can switch their fuel source from glucose to something else.
Read more: https://www.dovepress.com/oncotargets-and-therapy-journal
The strategy works as follows. First, Vitamin C inhibits glucose energy production, leaving the cancer cells without a way to produce energy. Glucose is the main source of energy for a sell. Once glucose is taken away from the cell, the cell then starves and dies. Then, a dose of the antibiotic keeps the cells from being able to switch to a new fuel source.
According to the researchers, this strategy is up to 100 times more effective than current cancer drug 2-DG. Not only that, but since both Vitamin C and Doxycycline are relatively non-toxic, the potential for side effects is greatly decreased. Download output styles at Endnote.com
The Oncotarget research team hopes that they can develop an effective cancer treatment based on the results of this study. They also identified other drugs that could replace Doxycycline in this combination therapy.
When a member of any family is diagnosed with cancer, such information affects such a family emotionally, psychologically and financially. Eric Lefkofsky was a wealthy entrepreneur behind the $2.2 billion company, Groupon. After learning how families feel when they are told about their next of kin having been diagnosed with the disease, he decided to become an advocate for cancer. In this new field, Eric is using his expertise on big data management to make significant changes in how the information is relayed to the people diagnosed with the illness and read full article.
Eric is married to Liz, a Chicago arts patron. Eric was saddened by the lack of adequate information in the field and the doctor’s unwillingness to assure cancer patients that they will be okay. He notes that such behavior scares families and patients and learn more about Eric.
By virtue of having first experience with cancer, the entrepreneur was able to identify the biggest problem in the industry. To this end, Eric concentrated on devising solutions that could bring sound and viable changes in the industry. He founded Tempus.
Tempus has created an operating system for cancer. The platform allows different medical institutions across the United States to share anatomic and molecular data. The centralization of this information allows doctors to be well informed and make better decisions. They will also be able to adequately advise their patients on different medications. Lefkofsky serves as the chief executive officer of the company.
With Tempus’ system, doctors will be able to adjust the combination of chemo and radio therapies on patients based on the data collected by the system. This information will include patients’ medical history, their genetic make-up, drugs that they take, and their responses to medication. Development of the system has taken over the billionaire’s life. Today, Eric is investing lesser on making himself wealthier. This is because he is trying to bring life into the healthcare industry.
Eric Paul Lefkofsky was born in Detroit in 1969. The American entrepreneur has founded several companies, including Lightbank, Echo Global Logistics, Mediaocean, and InnerWorkings. Eric has a sound educational background. He holds a degree in law from the renowned University of Michigan Law School. Eric has also appeared on Forbes’ Billionaires list severally.
Tempus is a company that is set out to provide better treatments for people suffering from breast cancer. Through the help of doctors and their data they hope that personal treatments can be treated that will be more effective at treating cancer. Tempus just partnered with the University of Chicago Medicine, and hope that through this partnerships, and work with other partnerships, that they can battle breast cancer.
Tempus is a essentially a database that doctors can use to find information faster that can then be used to create treatment plans for patients. These treatment plans are personal to each patient and therefore more effective at treating that specific patient than a generic treatment plan would be. Tempus hopes that their database, which is unlike any thing else, can fight and hopefully defeat cancer in patients.
Tempus was founded by Eric Lefkofsky, a man not new to the business game. Since his graduation from the University of Michigan Law School, he has created multiple successful companies that range in specialty. Tempus is something that Eric Lefkofsky created and is passionate about. He hopes that it will change the way breast cancer patients are treated for the better. His career is a tool that he uses to help create ways to better the world.
Eric Lefkofksy is also involved in many other organizations that have a positive impact on the community. He has created the Lefkofsky Family Foundation which is an organization that is aimed at bettering the communities they serve. Along with his organization he also serves on the board of other organizations. These organizations range from The Art Institute of Chicago to the Museum of Science and Industry. He is very passionate about the organization in which he is apart of and learn more about Eric.
Eric Lefkofsky is far more than a business man out to make a name for himself. Eric Lefkofsky wants to better the world and is doing that multiple ways. Through Tempus and his fight against cancer to his own foundation that aims at bettering the lives of people in his community, Eric Lefkofsky is dedicated to helping his fellow man.
More visit: www.forbes.com/profile/eric-lefkofsky